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Aromatase Inhibitors in Men: Effects and Treatment Options
Aromatase Inhibitors in Men: Effects and Therapeutic Options
Written by Willem de Ronde and Frank H de Jong
Abstract
Aromatase inhibitors (AIs) are drugs that block the
enzyme aromatase, which converts testosterone into estrogen. While initially developed for use
in women, AIs are now being explored for their potential benefits in men.
This article discusses the effects of AIs on hormone levels,
metabolism, and various therapeutic applications in men.
Background
Estrogens play a crucial role in male physiology, particularly in bone health, brain function, and
metabolic regulation. Aromatase is responsible
for the conversion of testosterone to estrogen, and its activity varies significantly among individuals.
Metabolism of estrogens in men
In men, aromatase produces estradiol, which is essential
for maintaining metabolic and bone health. Dysregulation of aromatase
can lead to conditions such as osteoporosis or obesity.
Phenotype of aromatase deficiency and excess
Aromatase deficiency is rare but can result in hypogonadism,
while excess activity may contribute to estrogen-related
conditions such as breast cancer.
Aromatase inhibitors
Aromatase inhibitors are drugs that block the enzyme’s
activity, thereby reducing estrogen levels. They have shown promise in treating hormone-sensitive cancers and metabolic disorders.
Effects of aromatase inhibition on luteinizing hormone release and testosterone production
Aromatase inhibitors can increase luteinizing hormone (LH) levels, which may enhance testosterone production.
Effects of aromatase inhibition in obese men
In obese individuals, AIs may improve metabolic
markers and reduce visceral fat.
Effects of aromatase inhibition on release of follicle-stimulating
hormone and spermatogenesis
Aromatase inhibitors may impact spermatogenesis,
with potential effects on fertility.
Effects of aromatase inhibition on bone metabolism and epiphysial closure
AIs may influence bone health, with potential benefits for conditions like osteoporosis.
Effects of aromatase inhibition on male breast
The impact of AIs on male breast health is an area of ongoing research.
Safety and concerns for aromatase inhibitors in men
Aromatase inhibitors may cause side effects such as hot flashes, bone loss, and cardiovascular risks.
Conclusion
Aromatase inhibitors hold promise for treating various conditions in men but require further research to fully understand their benefits and risks.
Competing interests
The authors declare no competing interests.
Authors’ contributions
Willem de Ronde and Frank H de Jong contributed to the article’s concept and writing.
Contributor Information
Both authors are researchers in the field of endocrinology.
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Aromatase Inhibitors in Men: Effects and Treatment Options
Aromatase Inhibitors in Men: Effects and Therapeutic Options
Written by Willem de Ronde and Frank H de Jong
Abstract
Aromatase inhibitors (AIs) are drugs that block the
enzyme aromatase, which converts testosterone into estrogen. While initially developed for use
in women, AIs are now being explored for their potential benefits in men.
This article discusses the effects of AIs on hormone levels,
metabolism, and various therapeutic applications in men.
Background
Estrogens play a crucial role in male physiology, particularly in bone health, brain function, and
metabolic regulation. Aromatase is responsible
for the conversion of testosterone to estrogen, and its activity varies significantly among individuals.
Metabolism of estrogens in men
In men, aromatase produces estradiol, which is essential
for maintaining metabolic and bone health. Dysregulation of aromatase
can lead to conditions such as osteoporosis or obesity.
Phenotype of aromatase deficiency and excess
Aromatase deficiency is rare but can result in hypogonadism,
while excess activity may contribute to estrogen-related
conditions such as breast cancer.
Aromatase inhibitors
Aromatase inhibitors are drugs that block the enzyme’s
activity, thereby reducing estrogen levels. They have shown promise in treating hormone-sensitive cancers and metabolic disorders.
Effects of aromatase inhibition on luteinizing hormone release and testosterone production
Aromatase inhibitors can increase luteinizing hormone (LH) levels, which may enhance testosterone production.
Effects of aromatase inhibition in obese men
In obese individuals, AIs may improve metabolic
markers and reduce visceral fat.
Effects of aromatase inhibition on release of follicle-stimulating
hormone and spermatogenesis
Aromatase inhibitors may impact spermatogenesis,
with potential effects on fertility.
Effects of aromatase inhibition on bone metabolism and epiphysial closure
AIs may influence bone health, with potential benefits for conditions like osteoporosis.
Effects of aromatase inhibition on male breast
The impact of AIs on male breast health is an area of ongoing research.
Safety and concerns for aromatase inhibitors in men
Aromatase inhibitors may cause side effects such as hot flashes, bone loss, and cardiovascular risks.
Conclusion
Aromatase inhibitors hold promise for treating various conditions in men but require further research to fully understand their benefits and risks.
Competing interests
The authors declare no competing interests.
Authors’ contributions
Willem de Ronde and Frank H de Jong contributed to the article’s concept and writing.
Contributor Information
Both authors are researchers in the field of endocrinology.
References
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